Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups.

doi:10.1016/j.ajhg.2020.04.002

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Article

Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups.

American journal of human genetics - 7 May 2020

Dikilitas Ozan, Schaid Daniel J, Kosel Matthew L, Carroll Robert J, Chute Christopher G, Denny Joshua A, Fedotov Alex, Feng QiPing, Hakonarson Hakon, Jarvik Gail P, Lee Ming Ta Michael, Pacheco Jennifer A, Rowley Robb, Sleiman Patrick M, Stein C Michael, Sturm Amy C, Wei Wei-Qi, Wiesner Georgia L, Williams Marc S, Zhang Yanfei, Manolio Teri A, Kullo Iftikhar J

Abstract excerpt

Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic ethnicity (HE) individuals is unclear. We investigated associations of "restricted" and genome-wide PRSs with CHD in three major racial and ethnic groups in the U.S. The eMERGE cohort (mean age 48 ± 14 years, 58% female) included 45,645...

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Identifiers

PMID: 32386537
DOI: 10.1016/j.ajhg.2020.04.002
PMCID: PMC7212267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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