Article

A Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization

2023-06-06

Abstract excerpt

<h4>Background</h4> Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (PRS CHD ) for 5 genetic ancestry groups. <h4>Methods</h4> We derived ancestry-specific and multi-ancestry PRS CHD based on pruning and thresholding (PRS P+T ) and continuous shrinkage priors (PRS CSx ) applied on summary statistics f...

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Literature Corpus work: 08f2b3d6-7369-5bea-a130-e62610f36173
DOI: 10.1101/2023.06.02.23290896

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