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Agomelatine drives sex-specific neuroprotection and reduced pathology in rat and human Alzheimer’s models

2026-01-21

Abstract excerpt

Alzheimer’s disease (AD) remains without effective disease-modifying therapies, underscoring the need for interventions that target interconnected molecular and cellular processes driving cognitive decline. Leveraging a cross-species translational framework integrating a progressive rat model of Alzheimer’s disease with human iPSC-derived neurons carrying familial AD mutations, we identify agomelatine (AGO) as a d...

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Literature Corpus work
9d811cbf-ca7c-5d5e-849f-dced6a476996
DOI
10.64898/2026.01.17.700104
Open publication

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