HypoAD: volumetric and single-cell analysis reveals changes in the human hypothalamus in aging and Alzheimer’s disease

Abstract excerpt

Alterations in metabolism, stress response, sleep, circadian rhythms, and neuroendocrine processes are key features of aging and neurodegeneration. These fundamental processes are regulated by the hypothalamus, yet how its functionally distinct subregions and cell types change during human aging and Alzheimer’s Disease (AD) remains largely unexplored. Here, we present HypoAD , a comprehensive atlas of the human h...

Topics

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• Alzheimer Disease
• Apolipoproteins E
• Brain
• Gene Expression Profiling
• Neuroinflammation and Neurodegeneration Mechanisms
• Sex Characteristics
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis

Identifiers and source

Literature Corpus work

c78620e4-894b-534a-b71b-3670a191aaf5

DOI

10.1101/2025.10.08.681270