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A mitochondrial-immune axis drives the transcriptomic transition from brain aging to Alzheimer’s disease

2026-06-05

Abstract excerpt

Aging is the primary risk factor for Alzheimer’s disease (AD), yet the molecular transitions linking normal brain aging to neurodegeneration remain poorly defined. Here, we performed integrative bulk transcriptomic analyses across a multi-region mouse aging atlas, a human aging-to-AD cohort, and an independent human AD validation dataset. Aging is associated with a progressive, region-specific increase in transcri...

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Literature Corpus work
918fef35-3d85-539e-ae91-05252f14c8d5
DOI
10.64898/2026.06.03.729900
Open publication

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A mitochondrial-immune axis drives the transcriptomic transition from brain aging to Alzheimer’s diseaseDOI 10.64898/2026.06.03.729900
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