Article

D-Methionine Improves Spatial Navigation and Attenuates Oxidative Stress and Amyloid Pathology in a Sex-Specific Manner

2026-01-30

Abstract excerpt

<h4>Background</h4> Oxidative stress and maladaptive neuroimmune activation contribute to cognitive decline in Alzheimer’s disease (AD) and represent therapeutic targets beyond amyloid-centered approaches. <h4>Objective</h4> To determine whether oral D-methionine (D-Met), a redox-active amino acid, reduces amyloid pathology and lipid peroxidation and confers disease-modifying benefits in AD mouse models. <h4>Met...

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Literature Corpus work: baf09bd8-8588-59ec-80ec-adeece8cf55f
DOI: 10.64898/2026.01.27.702104

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