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Single-Nucleus Transcriptomics Analysis Identifies Sex-Dichotomous Pathological Axes in Alzheimer’s Disease: Female Homeostatic Failure versus Male Neuroimmune Activation

2026-05-13

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<title>Abstract</title> <p> Background Alzheimer’s disease (AD) disproportionately affects females in both prevalence and clinical progression, yet the underlying sex-dependent cellular programs remain poorly understood. This study aims to delineate the sex-specific pathological landscape of AD at a single-nucleus resolution to identify the biological drivers of these disparities. We analyzed a large-scale inte...

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Literature Corpus work
58fdd261-a9d7-529c-a59b-62ac9c015a12
DOI
10.21203/rs.3.rs-9504119/v1
Open publication

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Single-Nucleus Transcriptomics Analysis Identifies Sex-Dichotomous Pathological Axes in Alzheimer’s Disease: Female Homeostatic Failure versus Male Neuroimmune ActivationDOI 10.21203/rs.3.rs-9504119/v1
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