Article

Longitudinal Metabolomic Profiling of Biogenic Amines in Plasma and CSF, and Their Correlation, Reveals Sex-Specific and Age Changes in TgF344 Alzheimer’s Disease Transgenic and Wildtype Rats

2025-12-08

Abstract excerpt

<h4>Background</h4> Alterations in amine metabolism have been implicated Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) and plasma are key biofluids in AD research. CSF is considered to better reflect brain metabolic alterations than plasma, while plasma can be obtained more easily. However, plasma-CSF relationships are unclear. <h4>Aim</h4> To investigate longitudinal changes of amines in plasma and CSF, a...

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Literature Corpus work: 40838042-fcce-541a-8f25-74b6d79e15eb
DOI: 10.64898/2025.12.03.692185

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