Article

Terazosin drives sex-dependent adrenergic–bioenergetic reprogramming to restore network function in Alzheimer’s disease

2026-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) has long been defined by amyloid-β plaques and hyperphosphorylated tau, yet disease-modifying therapies remain critically limited. Growing evidence reframes AD as a system-level failure driven by early dysregulation of synaptic, metabolic, and neuroimmune pathways, preceding overt protein aggregation and originating in selectively vulnerable circuits, including the locus...

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Literature Corpus work: 829c8bf4-793e-502b-9002-841d50704b1b
DOI: 10.64898/2026.04.02.716175

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