Article

Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer’s-like pathology

2025-06-15

Abstract excerpt

Aging is the strongest risk factor for cognitive decline and Alzheimer’s disease (AD), yet the mechanisms underlying brain aging and their modulation by pharmacological interventions remain poorly defined. The hippocampus, essential for learning and memory, is particularly vulnerable to metabolic stress and inflammation. Canagliflozin (Cana), an FDA-approved sodium-glucose co-transporter 2 inhibitor (SGLT2i) for t...

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Literature Corpus work: cd8a4988-f30f-581b-b644-ab39f85ce19c
DOI: 10.1101/2025.06.10.658747

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