Article

FGF8-mediated gene regulation affects regional identity in human cerebral organoids

2023-12-22

Abstract excerpt

<h4>SUMMARY</h4> The morphogen FGF8 establishes graded positional cues imparting regional cellular responses via modulation of early target genes. The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development. We used hiPSC-derived cerebral organoids as an in vitro platform to challenge the effect of FGF8 signaling on ne...

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Literature Corpus work: 9d5c883e-4973-545f-8d5a-276aeca983b2
DOI: 10.1101/2023.12.22.572974

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