Article

Distinct signaling center and progenitor identity dynamics initiate human forebrain patterning

2026-03-25

Abstract excerpt

At which developmental stage does the human brain start to differ from other mammals? We uncover human features of telencephalic patterning as early as the fourth post-conception week, comparing the early mouse and human forebrains using single-cell transcriptomics and 3D spatial multi-transcript imaging. In comparison to mice, the human telencephalon is delayed in ventral SHH signaling, accompanied by a human sig...

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Literature Corpus work: 0dfadf26-7f74-5c1b-b367-4ea6224f0789
DOI: 10.64898/2026.03.25.714146

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