Article

Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology

2025-09-03

Abstract excerpt

<h4>Summary</h4> The human neocortex exhibits characteristic regional patterning (arealization) critical for higher-order cognitive function. Disrupted arealization is strongly implicated in neurodevelopmental disorders (NDDs), but current neocortical organoid models largely fail to recapitulate this patterning, limiting mechanistic understanding. Here, we establish a straightforward method for generating arealiz...

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Literature Corpus work: c2272fc6-eca6-5630-89a8-6391b3041e2d
DOI: 10.1101/2025.09.02.672952

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