Article

Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

2024-05-19

Abstract excerpt

<h4>Summary</h4> The repertory of neurons generated by progenitor cells depends on their location along antero-posterior and dorso-ventral axes of the neural tube. To understand if recreating those axes was sufficient to specify human brain neuronal diversity, we designed a mesofluidic device termed Duo-MAPS to expose induced pluripotent stem cells (iPSC) to concomitant orthogonal gradients of a posteriorizing an...

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Literature Corpus work: 7922ab14-643d-5ffd-9ffe-86d17c97fc2d
DOI: 10.1101/2024.05.18.594828

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