Article

Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids

2021-02-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Biophysical factors such as shape and mechanical forces are known to play crucial roles in stem cell differentiation, embryogenesis and neurodevelopment. However, the complexity and experimental challenges capturing such early stages of development, and ethical concerns associated with human embryo and fetal research, limit our understanding of how these factors affect human...

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Literature Corpus work: f8a882aa-f3e3-5a2d-a310-b0331f6e259e
DOI: 10.1101/2021.02.18.431674

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