Article
A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids.
Nature methods - 1 Nov 2024
Bosone Camilla, Castaldi Davide, Burkard Thomas Rainer, Guzman Segundo Jose, Wyatt Tom, Cheroni Cristina, Caporale Nicolò, Bajaj Sunanjay, Bagley Joshua Adam, Li Chong, Sorre Benoit, Villa Carlo Emanuele, Testa Giuseppe, Krenn Veronica, Knoblich Jürgen Arthur
Abstract excerpt
Organoids generating major cortical cell types in distinct compartments are used to study cortical development, evolution and disorders. However, the lack of morphogen gradients imparting cortical positional information and topography in current systems hinders the investigation of complex phenotypes. Here, we engineer human cortical assembloids by fusing an organizer-like structure expressing fibroblast growth...
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