Article

Variation of human neural stem cells generating organizer states <i>in vitro</i> before committing to cortical excitatory or inhibitory neuronal fates

2019-03-15

Abstract excerpt

<h4>SUMMARY</h4> Better understanding the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here we used RNA-sequencing, cell imaging and lineage tracing of mouse and human in vitro NSCs to model the generation of cortical neuronal fates. We show that conserved signaling mechanisms regulate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9aa3bccc-2756-5c18-896e-70ec11fd2c60
DOI: 10.1101/577544

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Variation of human neural stem cells generating organizer states <i>in vitro</i> before committing to cortical excitatory or inhibitory neuronal fatesDOI 10.1101/577544Read

Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem CellsSemantic proximity Read

Single-cell transcriptomic analysis identifies neocortical developmental differences between human and mouseSemantic proximity Read

Brain regional identity and cell type specificity landscape of human cortical organoid modelsSemantic proximity Read

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCsSemantic proximity Read

Differentiation of human induced pluripotent stem cells into cortical neural stem cellsSemantic proximity Read

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.Semantic proximity Read

Expanding GABAergic Neuronal Diversity in PSC-Derived Disease ModelsSemantic proximity Read

Molecular programs of regional specification and neural stem cell fate progression in developing macaque telencephalonSemantic proximity Read

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortexSemantic proximity Read

Signal requirement for cortical potential of transplantable human neuroepithelial stem cellsSemantic proximity Read

Coupled transcriptomic divergence establishes a human-specific synaptic glial precursor stateSemantic proximity Read

FGF8-mediated gene regulation affects regional identity in human cerebral organoidsSemantic proximity Read