Article

Antibody Mediated Diversification of Primary and Secondary Humoral Immune Responses

2025-12-17

Abstract excerpt

Humoral immune responses are characterized by increasing antibody affinity and diversity over time. Increased affinity is mediated by a combination of immunoglobulin gene somatic mutation and iterative cycles of selection in germinal centers. Less is understood about how diversity increases. Here we examine the role of antibody feedback in diversifying immune responses in mice that produce B cells that are incapab...

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Literature Corpus work: 1f961482-2963-5677-b3b8-e32220e74e22
DOI: 10.64898/2025.12.15.694384

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