Article
Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response.
Cell host & microbe - 7 Oct 2020
McNamara Hayley A, Idris Azza H, Sutton Henry J, Vistein Rachel, Flynn Barbara J, Cai Yeping, Wiehe Kevin, Lyke Kirsten E, Chatterjee Deepyan, Kc Natasha, Chakravarty Sumana, Lee Sim B Kim, Hoffman Stephen L, Bonsignori Mattia, Seder Robert A, Cockburn Ian A
Abstract excerpt
Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here, we show that antibody titers to a key target, the repeat region of the Plasmodium falciparum circumsporozoite protein (PfCSP), plateaued after two immunizations in a clinical trial of the radiation-attenuated sporozoite vaccine. To understand the mechanisms limiting vaccine responsiveness, we developed...
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