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Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

19 Dec 2019

Abstract excerpt

Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses that are higher in magnitude and affinity than the primary response. These involve reengagement of memory B cell (MBC) clones, the diversity and specificity of which determine the breadth and effectiveness of the ensuing antibody response. Using prime-boost models in mice, we find that secondary responses are characterized by...

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PMID: 31866068
DOI: 10.1016/j.cell.2019.11.032

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