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Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein

6 Dec 2021

Abstract excerpt

Combinations of monoclonal antibodies (mAbs) against different epitopes on the same antigen synergistically neutralize many viruses. However, there are limited studies assessing whether combining human mAbs against distinct regions of the Plasmodium falciparum (Pf) circumsporozoite protein (CSP) enhances in vivo protection against malaria compared to each mAb alone or whether passive transfer of PfCSP mAbs would...

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PMID: 34871332
DOI: 10.1371/journal.ppat.1010133

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