Article

Activity-Induced MeCP2 Phosphorylation Regulates Retinogeniculate Synapse Refinement

2023-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in MECP2 give rise to Rett syndrome (RTT), an X-linked neurodevelopmental disorder that results in broad cognitive impairments in females. While the exact etiology of RTT symptoms remains unknown, one possible explanation for its clinical presentation is that loss of MeCP2 causes miswiring of neural circuits due to defects in the brain’s capacity to respond to changes in neuronal acti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c51fc3a-a2f2-51cb-83bf-ba43d244e7f7
DOI: 10.1101/2023.07.03.547549

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activity-Induced MeCP2 Phosphorylation Regulates Retinogeniculate Synapse RefinementDOI 10.1101/2023.07.03.547549Read

Recent advances in understanding synaptic abnormalities in Rett syndromeSemantic proximity Read

Rett syndrome: insights into genetic, molecular and circuit mechanisms.Semantic proximity Read

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.Semantic proximity Read

The role of MeCP2 in brain development and neurodevelopmental disorders.Semantic proximity Read

Deleting <i>Mecp2</i> from the entire cerebellum rather than its neuronal subtypes causes a delay in motor learning in miceSemantic proximity Read

Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndromeSemantic proximity Read

Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome.Semantic proximity Read

The enhancement of activity rescues the establishment of <i>Mecp2</i> null neuronal phenotypesSemantic proximity Read

Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome.Semantic proximity Read

Selective deletion of <i>Methyl CpG binding protein 2</i> from parvalbumin interneurons in the auditory cortex delays the onset of maternal retrieval in miceSemantic proximity Read

Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation.Semantic proximity Read

MECP2 regulates cortical plasticity underlying a learned behavior in adult female miceSemantic proximity Read