Recent advances in understanding synaptic abnormalities in Rett syndrome

Abstract excerpt

Rett syndrome is an extremely disabling X-linked nervous system disorder that mainly affects girls in early childhood and causes autism-like behavior, severe intellectual disability, seizures, sleep disturbances, autonomic instability, and other disorders due to mutations in the MeCP2 (methyl CpG-binding protein 2) transcription factor. The disorder targets synapses and synaptic plasticity and has been shown to di...

Topics

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• Brain Stem
• Excitatory Postsynaptic Potentials
• gamma-Aminobutyric Acid
• Methyl-CpG-Binding Protein 2
• Neural Inhibition
• Organ Culture Techniques
• Rett Syndrome
• Synaptic Transmission

Identifiers and source

Literature Corpus work

9a86508f-9021-5c2d-ac75-18f9636dab55

DOI

10.12688/f1000research.6987.1