Article
Rett syndrome: insights into genetic, molecular and circuit mechanisms.
Nature reviews. Neuroscience - 1 Jun 2018
Ip Jacque P K, Mellios Nikolaos, Sur Mriganka
Abstract excerpt
Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT have greatly advanced our understanding of the function and regulation of the multifunctional protein MeCP2. Here, we review recent advances in understanding how loss of MeCP2 impacts different stages of brain development, discuss recent...
Topics
- Animals
- Brain
- Cell Differentiation
- Epigenesis, Genetic
- Gene Expression Regulation, Developmental
- Humans
- Methyl-CpG-Binding Protein 2
- MicroRNAs
- Mutation
- Neurons
- Rett Syndrome