Article

The enhancement of activity rescues the establishment of <i>Mecp2</i> null neuronal phenotypes

2020-04-07

Abstract excerpt

Mecp2 deficiency, the gene responsible for Rett syndrome (RTT), affects brain maturation by impairing neuronal activity, transcription and morphology. These three elements are physiologically linked in a feed-forward cycle where neuronal activity modulates transcription and morphology to further increase network maturity. We hypothesized that the reduced activity displayed by maturing Mecp2 null neurons during de...

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Literature Corpus work: 5b3406fd-b306-5bea-8f61-79dae889ad6b
DOI: 10.1101/2020.04.06.027995

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