Article

Deleting <i>Mecp2</i> from the entire cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

2020-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Rett syndrome is a devastating childhood neurological disorder caused by mutations in MECP2 . Of the many symptoms, motor deterioration is a significant problem for patients. In mice, deleting Mecp2 from the cortex or basal ganglia causes motor dysfunction, hypoactivity, and tremor, which are abnormalities observed in patients. However, little is known about the consequences of deleting Mecp2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e3f1601-7a18-56fd-9d67-6292adbbbf9e
DOI: 10.1101/2020.11.12.380162

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deleting <i>Mecp2</i> from the entire cerebellum rather than its neuronal subtypes causes a delay in motor learning in miceDOI 10.1101/2020.11.12.380162Read

MeCP2 is Necessary in Cerebellar Purkinje Cells for Precise Network Dynamics During Associative Motor LearningSemantic proximity Read

Rett syndrome: insights into genetic, molecular and circuit mechanisms.Semantic proximity Read

Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3.Semantic proximity Read

Activity-Induced MeCP2 Phosphorylation Regulates Retinogeniculate Synapse RefinementSemantic proximity Read

Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndromeSemantic proximity Read

MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning.Semantic proximity Read

Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis.Semantic proximity Read

MeCP2-mediated alterations of striatal features accompany psychomotor deficits in a mouse model of Rett syndrome.Semantic proximity Read

Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome.Semantic proximity Read

Deciphering MECP2-associated disorders: disrupted circuits and the hope for repair.Semantic proximity Read

Mild overexpression of MeCP2 causes a progressive neurological disorder in mice.Semantic proximity Read

<i>MECP2</i> -mutant marmosets exhibit primate-specific phenotypes of Rett syndromeSemantic proximity Read