Article

MECP2 regulates cortical plasticity underlying a learned behavior in adult female mice

2016-02-28

Abstract excerpt

<h4>ABSTRACT</h4> Neurodevelopmental disorders begin with the emergence of inappropriate synaptic connectivity early in life, yet how the sustained disruption of experience-dependent plasticity aggravates symptoms in adulthood is unclear. Here we used pup retrieval learning to assay adult cortical plasticity in a female mouse model of Rett syndrome ( MeCP2 het ). We show that auditory cortical plasticity and re...

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Literature Corpus work: 9f5fb9d3-cbf2-58c6-bf91-5ba186d5eb7b
DOI: 10.1101/041707

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