Article

Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome

2022-04-25

Abstract excerpt

Rett syndrome is characterized by an early period of typical development and then, regression of learned motor and speech skills in girls. Loss of MECP2 protein is thought to cause Rett syndrome phenotypes. The specific underlying mechanisms from typical developmental trajectory to regression features throughout life are unclear. Lack of established timelines to study the molecular, cellular, and behavioral featur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 34dcde9a-27a2-5529-91cf-4358ea0e02d5
DOI: 10.1101/2022.04.25.482695

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndromeDOI 10.1101/2022.04.25.482695Read

Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome.Semantic proximity Read

MECP2 regulates cortical plasticity underlying a learned behavior in adult female miceSemantic proximity Read

Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering.Semantic proximity Read

Sex differences in Mecp2-mutant Rett syndrome model mice and the impact of cellular mosaicism in phenotype development.Semantic proximity Read

Mecp2 deletion results in profound alterations of developmental and adult functional connectivitySemantic proximity Read

Early transcriptional signatures of MeCP2 positive and negative cells in Rett syndromeSemantic proximity Read

Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation.Semantic proximity Read

Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome.Semantic proximity Read

Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome.Semantic proximity Read

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progressionSemantic proximity Read

Activity-Induced MeCP2 Phosphorylation Regulates Retinogeniculate Synapse RefinementSemantic proximity Read

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression.Semantic proximity Read