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Article

Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome.

Journal of neuroscience research - 1 Aug 2023

Mykins Michael, Layo-Carris Dana, Dunn Logan Reid, Skinner David Wilson, McBryar Alexandra Hart, Perez Sarah, Shultz Trinity Rose, Willems Andrew, Lau Billy You Bun, Hong Tian, Krishnan Keerthi

Abstract excerpt

Rett syndrome is characterized by an early period of typical development and then, regression of learned motor and speech skills in girls. Loss of MECP2 protein is thought to cause Rett syndrome phenotypes. The specific underlying mechanisms from typical developmental trajectory to regression features throughout life are unclear. Lack of established timelines to study the molecular, cellular, and behavioral...

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Identifiers

PMID: 37026482
DOI: 10.1002/jnr.25190
PMCID: PMC10332853

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