Article
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.
Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2009
Tao Jifang, Hu Keping, Chang Qiang, Wu Hao, Sherman Nicholas E, Martinowich Keri, Klose Robert J, Schanen Carolyn, Jaenisch Rudolf, Wang Weidong, Sun Yi Eve
Abstract excerpt
Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been reported, the full spectrum of MeCP2 phosphorylation together with the in vivo function of such modifications are yet...
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