Article
Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation.
Human molecular genetics - 1 May 2016
Du Fang, Nguyen Minh Vu Chuong, Karten Ariel, Felice Christy A, Mandel Gail, Ballas Nurit
Abstract excerpt
Germline mutations in the X-linked gene, methyl-CpG-binding protein 2 (MECP2), underlie most cases of Rett syndrome (RTT), an autism spectrum disorder affecting approximately one in 10 000 female live births. The disease is characterized in affected girls by a latent appearance of symptoms between 12 and 18 months of age while boys usually die before the age of two. The nature of the latency is not known, but...
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