Article

Enforced MYC expression selectively redirects transcriptional programs during human plasma cell differentiation

2024-04-21

Abstract excerpt

MYC provides a rheostat linking cell growth and division during plasma cell (PC) differentiation. Precise control of MYC is central to the network controlling differentiation. Deregulation of MYC drives transformation in aggressive B-cell neoplasms and is often accompanied by apoptotic protection conferred by BCL2. We assess how MYC and BCL2 deregulation impacts on the ability of human B-cells to complete PC diffe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c4fe9b1-70cb-5ed0-8cd5-f365680c4f5e
DOI: 10.1101/2024.04.18.589889

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enforced MYC expression selectively redirects transcriptional programs during human plasma cell differentiationDOI 10.1101/2024.04.18.589889Read

A dichotomy in association of core transcription factors and gene regulation during the activated B-cell to plasmablast transitionSemantic proximity Read

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell AnalysesSemantic proximity Read

Differential transcriptional reprogramming by wild type and lymphoma-associated mutant MYC proteins as B-cells convert to lymphoma-like cellsSemantic proximity Read

Generation of human long-lived plasma cells by developmentally regulated epigenetic imprintingSemantic proximity Read

The transcriptional program of a human B cell line in response to MycSemantic proximity Read

Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation.Semantic proximity Read

Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiationSemantic proximity Read

Conserved epigenetic programming and enhanced heme metabolism drive memory B cell reactivationSemantic proximity Read

Growth-factor like gene regulation is separable from survival and maturation in antibody secreting cellsSemantic proximity Read

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesisSemantic proximity Read

Sustained MYC overexpression drives myeloid differentiation block and acquisition of leukemic phenotypes.Semantic proximity Read

Novel targeted deregulation of c-Myc cooperates with Bcl-XL to cause plasma cell neoplasms in miceSemantic proximity Read