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Article

Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation

26 Nov 2013

Abstract excerpt

The transcriptional repressors BCL6 and BACH2 are crucial regulators of germinal center (GC) B-cell fate, and are known to interact and repress transcription of PRDM1, a key driver of plasma cell differentiation. How these factors cooperate is not fully understood. Herein, we show that GC formation is only minimally impaired in Bcl6(+/-) or Bach2(+/-) mice, although double heterozygous Bcl6(+/-)Bach2(+/-) mice...

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PMID: 24277074
DOI: 10.1182/blood-2013-07-518605

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