Article

Growth-factor like gene regulation is separable from survival and maturation in antibody secreting cells

2018-10-11

Abstract excerpt

Recurrent mutational activation of the MAP kinase pathway in plasma cell myeloma implicates growth factor-like signaling responses in the biology of antibody secreting cells (ASCs). Physiological ASCs survive in niche microenvironments, but how niche signals are propagated and integrated is poorly understood. Here we dissect such a response in human ASCs using an in vitro model. Applying time course expression dat...

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Literature Corpus work: c85d5b51-6d45-5d6d-bb2b-7de496ef4984
DOI: 10.1101/439752

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