Article

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses

2023-01-20

Abstract excerpt

Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASC) to long-lived plasma cells (LLPC). We provide single cell transcriptional resolution of 17,347 BM ASC from 5 healthy adults. Fifteen clusters were identified ranging from newly minted ASC (cluster 1) expressing MKI67 and high MHC Class II that progressed to late clusters 5-8 through intermediate cluster...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d25bd3fd-4a5a-505e-b17a-26a2076de393
DOI: 10.1101/2023.01.18.524601

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell AnalysesDOI 10.1101/2023.01.18.524601Read

Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analysesSemantic proximity Read

Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiationSemantic proximity Read

Single‐cell resolution of plasma cell fate programming in health and diseaseSemantic proximity Read

Multi-omic profiling of human antibody-secreting cells reveals diverse subsets sustain durable humoral immunitySemantic proximity Read

Integrated single-cell (phospho-)protein and RNA detection uncovers phenotypic characteristics of human antibody secreting cellsSemantic proximity Read

High-resolution single-cell atlas of the human B cell compartment and immune microenvironment across tissuesSemantic proximity Read

Generation of human long-lived plasma cells by developmentally regulated epigenetic imprintingSemantic proximity Read

Integrated Single-Cell (Phospho-)Protein and RNA Detection Uncovers Phenotypic Characteristics and Active Signal Transduction of Human Antibody-Secreting Cells.Semantic proximity Read

Unraveling B cell trajectories at single cell resolutionSemantic proximity Read

Plasma cells in immunopathology: concepts and therapeutic strategies.Semantic proximity Read

Differential transcriptome and development of human peripheral plasma cell subsetsSemantic proximity Read

Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic RegulationSemantic proximity Read