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Article

Sustained MYC overexpression drives myeloid differentiation block and acquisition of leukemic phenotypes.

Experimental hematology - 1 May 2026

Stokes Nicole, Carcamo Saul, Demircioglu Deniz, Wang Xuedi, Olszewska Malgorzata, Hasson Dan, Watanabe Hideo, Papapetrou Eirini P, Dominguez-Sola David

Abstract excerpt

Overexpression of MYC is a common convergent consequence of genetic driver mutations in acute myeloid leukemia (AML). However, despite extensive research, the mechanisms by which this proto-oncogene promotes leukemogenesis remain incompletely understood. Here, we developed models of deregulated MYC expression in human pluripotent stem cell (hPSC)-derived myelopoiesis. We demonstrate that MYC overexpression from...

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Share to Cell Transformation, Neoplastic
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Myelopoiesis

Share to Pluripotent Stem Cells

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-myc

Source

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Identifiers

PMID: 41796634
DOI: 10.1016/j.exphem.2026.105403
PMCID: PMC13245593

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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