Article
Differential transcriptional reprogramming by wild type and lymphoma-associated mutant MYC proteins as B-cells convert to lymphoma-like cells
2020-07-14
Abstract excerpt
The transcription factor MYC regulates the expression of a vast number of genes and is implicated in various human malignancies, for which it’s deregulation by genomic events such as translocation or amplification can be either disease-defining or associated with poor prognosis. In hematological malignancies MYC is frequently subject to missense mutations and one such hot spot where mutations have led to increased...
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Identifiers and source
- Literature Corpus work
- bd281c3b-fc1f-51a6-8ee7-e5a1a3cd77f3
- DOI
- 10.1101/2020.07.13.200238