Article

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis

2023-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Somatic missense mutations in the phosphodegron domain of the MYC gene ( M YC Box I) are detected in the dominant clones of a subset of acute myeloid leukemia (AML) patients, but the mechanisms by which they contribute to AML are unknown. To unveil unique proprieties of MBI MYC mutant proteins, we systematically compared the cellular and molecular consequences of expressing similar oncogenic l...

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Literature Corpus work: 87bf7a6a-6ecc-5b36-ac6a-e3c0ada38e24
DOI: 10.1101/2023.10.22.563493

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