Article

Conserved epigenetic programming and enhanced heme metabolism drive memory B cell reactivation

2021-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Memory B cells (MBCs) have enhanced capabilities to differentiate to plasma cells and generate a rapid burst of antibodies upon secondary stimulation. To determine if MBCs harbor an epigenetic landscape that contributes to increased differentiation potential, we derived the chromatin accessibility and transcriptomes of influenza-specific IgM and IgG MBCs compared to naïve cells. MBCs possessed a...

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Literature Corpus work: 6a8de100-c8b4-55b3-8ba9-801097475fe3
DOI: 10.1101/2021.01.20.427446

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