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Article

Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting

24 Dec 2021

Abstract excerpt

Antibody secreting cells (ASCs) circulate after vaccination and infection and migrate to the BM where a subset known as long-lived plasma cells (LLPCs) persists and secrete antibodies for a lifetime. The mechanisms by which circulating ASCs become LLPCs are not well elucidated. Here, we show that human blood ASCs have distinct morphology, transcriptomes, and epigenetics compared with BM LLPCs. Compared with blood...

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PMID: 34952892
DOI: 10.26508/lsa.202101285

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