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Article

Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation.

Journal of biochemistry - 1 Jun 2007

Igarashi Kazuhiko, Ochiai Kyoko, Muto Akihiko

Abstract excerpt

Upon antigen stimulation, B lymphoid cells undergo terminal differentiation into antibody-secreting plasma cells. This process accompanies drastic changes in cell functions such as a loss of B-cell identity, induction of secretory apparatus, and an extremely increased transcription of antibody genes. These changes are the result of re-wiring of a transcription factor network in B and plasma cells. While the...

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B-Lymphocytes
Cell Differentiation
Models, Biological
Plasma Cells
Positive Regulatory Domain I-Binding Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Repressor Proteins

Transcription, Genetic

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PMID: 17569706
DOI: 10.1093/jb/mvm106

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