Article

Novel targeted deregulation of c-Myc cooperates with Bcl-XL to cause plasma cell neoplasms in mice

2004-06-15

Abstract excerpt

Deregulated expression of both Myc and Bcl-X(L) are consistent features of human plasma cell neoplasms (PCNs). To investigate whether targeted expression of Myc and Bcl-X(L) in mouse plasma cells might lead to an improved model of human PCN, we generated Myc transgenics by inserting a single-copy histidine-tagged mouse Myc gene, Myc(His), into the mouse Ig heavy-chain Cα locus. We also generated Bcl-X(L) transgeni...

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Identifiers and source

Literature Corpus work: 084071e2-8119-57d7-8ee9-f61f7e427a81
DOI: 10.1172/jci200420369

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