Article

Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactions

2024-07-24

Abstract excerpt

<h4>Background</h4> Genomic variations contribute to the phenotypic diversity of individuals. A number of polymorphisms in protein-coding regions that alter drug efficacy or lead to adverse reactions have been characterized; however, noncoding regions that affect drug responses are largely overlooked, except for a limited number of well-studied enhancers. <h4>Results</h4> We conducted a quantitative assessment o...

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Literature Corpus work: 9c2f04b4-9b85-5ea2-b470-10dc8a484c40
DOI: 10.1101/2024.07.24.604883

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