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Article

Functional characterization of liver enhancers that regulate drug-associated transporters.

Clinical pharmacology and therapeutics - 1 Apr 2011

Kim M J, Skewes-Cox P, Fukushima H, Hesselson S, Yee S W, Ramsey L B, Nguyen L, Eshragh J L, Castro R A, Wen C C, Stryke D, Johns S J, Ferrin T E, Kwok P-Y, Relling M V, Giacomini K M, Kroetz D L, Ahituv N

Abstract excerpt

Little is known about how genetic variations in enhancers influence drug response. In this study, we investigated whether nucleotide variations in enhancers that regulate drug transporters can alter their expression levels. Using comparative genomics and liver-specific transcription factor binding site (TFBS) analyses, we identified evolutionary conserved regions (ECRs) surrounding nine liver membrane...

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Identifiers

PMID: 21368754
DOI: 10.1038/clpt.2010.353
PMCID: PMC3227682

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ABCB11

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