Article

Massively parallel reporter assays for <i>CYP3A4</i> enhancer variants alongside their native promoter

2026-04-24

Abstract excerpt

Massively parallel reporter assays (MPRAs) enable high-throughput functional testing of thousands of cis -regulatory elements (CREs). However, conventional MPRAs typically use short CRE fragments combined with minimal promoters, which limits their ability to capture native regulatory interactions. Here, we present a modified MPRA framework that assays CREs together with their target promoter. We apply this approa...

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Literature Corpus work: d6d39a48-646c-5798-b16d-cb1149a4bdc0
DOI: 10.64898/2026.04.22.719677

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