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Article

Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5.

Clinical and translational science - 1 Nov 2022

Collins Joseph M, Nworu Adaeze C, Mohammad Somayya J, Li Liang, Li Chengcheng, Li Chuanjiang, Schwendeman Ethan, Cefalu Mattew, Abdel-Rasoul Mahmoud, Sun Jessie W, Smith Sakima A, Wang Danxin

Abstract excerpt

The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis-acting genetic elements that control the expression of the CYP3As remain uncharacterized. Using chromatin conformation capture (4C assays), we detected reciprocal...

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Share to Cytochrome P-450 CYP3A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36045613
DOI: 10.1111/cts.13398
PMCID: PMC9652438

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