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Germline <i>cis</i> variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase ( <i>DPYD</i> )

2023-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Enhancers are critical for regulating tissue-specific gene expression, and genetic variants within enhancer regions have been suggested to contribute to various cancer-related processes, including therapeutic resistance. However, the precise mechanisms remain elusive. Using a well-defined drug-gene pair, we identified an enhancer region for dihydropyrimidine dehydrogenase (DPD, DPYD gene) expre...

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Literature Corpus work
198886e7-2fe4-59b4-a077-2a3950f0ada2
DOI
10.1101/2023.11.01.565230
Open publication

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Germline <i>cis</i> variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase ( <i>DPYD</i> )DOI 10.1101/2023.11.01.565230
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