Article
Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver.
Human molecular genetics - 15 Oct 2014
Liu Wanqing, Ramírez Jacqueline, Gamazon Eric R, Mirkov Snezana, Chen Peixian, Wu Kehua, Sun Chang, Cox Nancy J, Cook Edwin, Das Soma, Ratain Mark J
Abstract excerpt
The aim of this study was to discover cis- and trans-acting factors significantly affecting mRNA expression and catalytic activity of human hepatic UDP-glucuronosyltransferases (UGTs). Transcription levels of five major hepatic UGT1A (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) and five UGT2B (UGT2B4, UGT2B7, UGT2B10, UGT2B15 and UGT2B17) genes were quantified in human liver tissue samples (n = 125) using...
Topics
- DNA Copy Number Variations
- Gene Expression Regulation
- Genetic Variation
- Glucuronosyltransferase
- Humans
- Liver
- Peroxisome-Targeting Signal 1 Receptor
- Polymorphism, Single Nucleotide
- Receptors, Cytoplasmic and Nuclear