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Article

Cis-acting regulatory elements regulating CYP3A4 transcription in human liver.

Pharmacogenetics and genomics - 1 Jul 2020

Collins Joseph M, Wang Danxin

Abstract excerpt

The CYP3A4 enzyme is the most abundant drug-metabolizing enzyme in the liver, metabolizing ~50% of commonly used medications. CYP3A4 displays large interperson variability in expression and enzyme activity with unknown causes. This study aims to identify cis-acting regulatory elements controlling the transcription of CYP3A4, using chromatin conformation capture (4C and 3C assays), chromatin immunoprecipitation...

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Share to Aryl Hydrocarbon Hydroxylases
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Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32301865
DOI: 10.1097/FPC.0000000000000402
PMCID: PMC8457025

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