Article
An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.
Nature communications - 9 Mar 2022
Shen Ting, Ni Ting, Chen Jiaxuan, Chen Haitao, Ma Xiaopin, Cao Guangwen, Wu Tianzhi, Xie Haisheng, Zhou Bin, Wei Gang, Saiyin Hexige, Shen Suqin, Yu Peng, Xiao Qianyi, Liu Hui, Gao Yuzheng, Long Xidai, Yin Jianhua, Guo Yanfang, Wu Jiaxue, Wei Gong-Hong, Hou Jinlin, Jiang De-Ke
Abstract excerpt
Most cancer causal variants are found in gene regulatory elements, e.g., enhancers. However, enhancer variants predisposing to hepatocellular carcinoma (HCC) remain unreported. Here we conduct a genome-wide survey of HCC-susceptible enhancer variants through a three-stage association study in 11,958 individuals and identify rs73613962 (T > G) within the intronic region of PRMT7 at 16q22.1 as a susceptibility...
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